Meet the scientists of ISBUC
Click on the links below to read about the scientists associated with ISBUC.
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Alexander Schultz
Professor, Department of Plant and Environmental Science, Section for Transport Biology
Structure-function relationship of symplasmic transport in plants using non-invasive Bioimaging to visualise and quantify plant cell communication across plasmodesmata
Keywords: Plasmodesmays communication phloem
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Amelie Stein
Assistant professor, Department of Biology
Consequences of protein sequence changes on structure, function and phenotype
Keywords: structural computational biology, variant consequences, MAVE
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Anja Tatiana Ramstedt Jensen
Professor, Department of Immunology and Microbiology
Structural and in vitro molecular and immunological characterization of proteins associated with severe malaria in young children.
Keywords: malaria, pathogenesis, immunity, variant surface antigens, ICAM1, adhesion, molecular interactions, immunology and the immune defence, malaria immunology, malaria vaccine
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Annette Eva Langkilde
Associate professor, Department of Drug Design and Pharmacology
Structural analysis of proteins in solution. SAXS. Protein protein interactions. Protein fibrillation and formation of amyloids and amyloid-like structures.
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Azadeh Shahsavar
Assistant professor, Department of Drug Design and Pharmacology
We aim to reveal the molecular details of glycine and glutamine transport using a multidisciplinary approach including structural studies by Cryo-EM and/or X-ray crystallography, and a range of biophysical and biochemical methods.
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Birthe B. Kragelund
Professor, Department of Biology
Dynamic Protein-Protein Interactions - Understanding Functional Interactions from a Structural Dynamics Platform
Keywords: NMR, Intrinsically Disordered Proteins, membrane proteins, protein interactions
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Celine Galvagnion-Büll
Associate professor, Department of Drug Design and Pharmacology
Our research aims at providing mechanistic insights into the interplay between disruptions in lipid homeostasis and Parkinson's Disease. We use a multidisciplinary approach at the interface between biology and biophysics including the study of different patients derived samples and the characterisation of protein-membrane interactions and aggregation at the molecular level.
Keywords: Parkinson's disease, Amyloid fibrils, Alpha-synuclein, Lipid, Kinetic analysis, Biophysics, Cellular biology, Molecular biology
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Christian Adam Olsen
Professor, Center for Biopharmaceuticals
Synthesis and evaluation of biologically active peptidomimetics and macrocyclic peptides
Keywords: Foldamers, macrocycles, post translational modifications, epigenetics, affinity-based probes
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Claus Juul Løland
Professor, Department of Neuroscience
Elucidation of structure-function relationships in secondary active transporters
Keywords: neurotransmitter transporters, fluorescence, x-ray crystallography, functional reconstitution, membrane protein purification, molecular pharmacology, drug discovery,
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David Gloriam
Associate professor, Drug Design and Pharmacology Department
Structure-based drug design and GPCR crystallography
Keywords: GPCR, computational drug design, crystallisation construct design, database development
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Dimitrios Stamou
Professor, Department of Chemistry
Disruptive technologies to study the biophysical properties of membranes and membrane proteins on the nanoscale using fluorescence microscopy.
Keywords: Nanoscale membrane biophysics, membrane proteins, membrane curvature, single molecules, fluorescence microscopy, Ras, G protein coupled receptors, primary and secondary active transporters.
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Eva Kummer
Associate professor, Novo Nordisk Foundation Center for Protein Research
Working Principles of Molecular Machines involved in Mitochondrial Genome Maintenance & Gene Expression
Keywords: mitochondria, protein-DNA interactions, protein-RNA interactions, electron microscopy, biophysics, biochemistry
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Flemming Steen Jørgensen
Professor, Department of Drug Design and Pharmacology
Computational chemistry and prediction of drug metabolism
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Guillermo Montoya
Professor, Novo Nordisk Foundation Center for Protein Science
Molecular understanding of macromolecules involved in cell cycle and genome instability.
Keywords: protein-DNA interaction, X-ray, Electron Microscopy, Biophysics
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Heloisa Nunes Bordallo
Associate professor, Niels Bohr Institute
solving scientific questions where complex dynamics play an important role on physical properties.
Keywords: water dynamics, hydrogen bonds, metastable states
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Henriette Autzen
Associate professor, Section for Biomolecular Sciences and SBiNLab
Structural and functional xharacterization of mammalian membrane proteins involved in taste-signaling with single-particle cryo-EM and complimentary techniques.
Keywords: cryo-EM, membrane proteins, pharmacology, biochemistry
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Jacob Kirkensgaard
Associate professor, Food
Soft matter self-assembly, structural food science - primarily using small-angle scattering but also light scattering, rheology, imaging and coarse grained simulations
Keywords: self-assembly structural food science soft matter
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Jette Sandholm Kastrup
Professor, Department of Drug Design and Pharmacology
The goal is to obtain detailed understanding of ligand-gated ion channel receptor structure and function, which is essential for providing a rational basis for design of therapeutic strategies for treating diseases and disorders within the central nervous system.
Keywords: Structural biology on receptors and soluble domains hereof; protein X-ray and neutron crystallography, protein-ligand and protein-protein interactions, structure-based ligand design; ionotropic glutamate receptors
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Joseph Rogers
Associate professor, Department of Drug Design and Pharmacology
Discovery of new drug-like cyclic peptides for disease-relevant proteins, including biophysical and structural characterisation of the discovered molecules.
Keywords: Peptide display, Unnatural amino acids, Cyclic peptides, Protein folding, Intrinsically disordered proteins
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Karen L. Martinez
Associate professor, Dpt of Chemistry & Nano Science Center
Bionanoscience for Membrane Proteins group (BioMeP)
- Use of new biochemical and biophysical tools to investigate membrane proteins isolated and in cells
- Use of nanomaterials for novel cell assays.
Keywords: GPCR, membrane proteins, amphipols, nanodiscs, nanomaterials, surface sensitive techniques,fluorescence,
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Kasper D. Rand
Associate professor, Department of Pharmacy
Analysis of the primary structure of proteins by liquid chromatography and mass spectrometry (LC-MS). As well as analysis of the higher-order structure and molecular interactions of proteins and protein systems by hydrogen/deuterium exchange mass spectrometry (HDX-MS).
Keywords: Bioanalytical Chemistry, Protein Analytical Chemistry, HDX-MS, Protein Mass Spectrometry
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Kell Mortensen
Professor, Niels Bohr Institute
Biophysics and soft matter studies, with main emphasis on self-assembly, biomaterials and synthetic biology
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Klaus Qvortrup
Professor, CFIM (Core Facility for Integrated Microscopy), Department of Biomedical Science
Director of CFIM (Core Facility for Integrated Microscopy)
Keywords: Microscopy
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Kresten Lindorff-Larsen
Professor, Department of Biology
Molecular dynamics simulations restrained by experimental data and Relationship between protein structure, function and dynamics
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Kaare Teilum
Associate professor, Department of Biology
Link between protein dynamics and function using NMR spectroscopy to look at protein misfiling, enzyme catalysis and membrane transport.
Keywords: NMR, Protein dynamics, enzyme stability
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Lars Bo Stegeager Hemmingsen
Associate professor, Department Of Chemistry
Exploring the role of metal ions in biological systems using various spectroscopic techniques. Current interests: Cu(II) and Zn(II) in Alzheimer's disease, metalloregulatory proteins, ultrasensitive radioisotope based NMR.
Keywords: Metal ions, proteins, spectroscopy
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Leila Lo Leggio
Associate professor, Department Of Chemistry
Structural biology of carbohydrate-active, other biotechnology relevant enzymes and transcription factor.
Keywords: Biochemistry, Carbohydrate-active enzymes, transcription factors
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Lise Arleth
Professor, Niels Bohr Institute
Structure and Self-assembly of Lipid and Protein based systems Small-Angle X-ray and Neutron Scattering (SAXS/SANS) experiments and analysis
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Martin Gustavsson
Assistant professor, Department of Biomedical Sciences
Structure, dynamics and function of 7TM G protein-coupled receptors.
Keywords: Membrane proteins, 7TM receptors, protein-protein and protein-lipid interactions, receptor pharmacology and signaling
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Martin Willemoës
Associate professor, Linderstrøm-Lang Centre for Protein Science
Enzyme engineering and design. Development of selection systems for accelerated evolution of enzyme activities.
Keywords: enzymology, protein engineering, bacterial genetics
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Mette Marie Rosenkilde
Professor, Department of Neuroscience and Pharmacology
Basic pharmacology within the area of 7TM receptors
Keywords: incretin hormones, 7TM G protein coupled receptors, virus-exploited 7TM receptors
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Michael Gajhede
Professor, Drug Design and Pharmocology Department
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Michal Tomasz Marzec
Associate professor, Department of Biomedical Sciences
Proinsulin folding- new necessary steps (type 2 diabetes) and their relationship to degradation and antigen presentation (type 1 diabetes).
Keywords: protein folding, endoplasmic reticulum
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Morten Bjerrum
Professor, Department of Chemistry
Bioinorganic Chemistry - Metal ions in biological systems: structure, function, binding, shuttling and exchange - Structure and function of redox active metalloenzymes in metabolic and biotechnological processes
Keywords: Bioinorganic Chemistry
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Morten Meldal
Professor, Center for Evolutionary Chemical Biology
Artificial small molecule antibodies and enzymes for medicine and diagnostics using state of the art combinatorial technology
Keywords: Molecular recognition and processing, Artificial antibodies and enzymes, Combinatorial technology, Peptide - organic solid phase synthesis, Polymers, Cell signaling, Molecular modelling and NMR spectroscopy.
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Nicholas M I Taylor
Associate professor, Novo Nordisk Foundation Centre for Protein Research
Structural Biology of Molecular Machines
Keywords: cryo-electron microscopy (cryo-EM), structural biology, bacteriophages, bacterial secretion systems, contractile injection systems, membrane transport
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Nikos Hatzakis
Associate professor, Nano Science Center
Advanced fluorescent microscopy and single molecule techniques for deciphering protein dynamics and their role in regulation of protein activity and plasticity
Keywords: Single molecule, microscopy, biophysics,
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Osman Mirza
Associate professor, Department of Drug Design and Pharmacology
Interplay between (un)natural compounds and secondary transporters involved in health and disease.
Keywords: X-ray crystallography, EM, Transporters, Structure, Function
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Per Mårten Hägglund
Associate professor, Department of Biomedical Sciences
Mechanisms of protein oxidation and its influence on protein structure and function
Keywords: Mass spectrometry, protein oxidation, cross-linking, extracellular matrix proteins
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Peter Waaben Thulstrup
Associate professor, Department Of Chemistry
Protein and nucleic acid structures and development of their synthetic modification as tools to investigate aspects of biological chemistry
Keywords: Circular dichroism, fluorescence, electronic structure, excited states, pharmaceutical proteins, bioinorganic chemistry, metal ions, nanoclusters, biosensors
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Pontus Gourdon
Associate professor, Department of Biomedical Science
The overarching aim is to reveal the molecular principles and determinants of medically relevant transport processes across cellular membranes
Keywords: membrane proteins, structure, function
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Poul Martin Bendix
Associate professor, Niels Bohr Institute
Mechanosensing of cell shapes and dynamics of membrane proteins using advanced optical tools.
Keywords: Filopodia dynamics, membrane curvature, membrane tubes, BAR domain proteins, optical manipulation of membranes, Optically controlled fusion of membranes and cells
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Robert Feidenhansl
Professor, European XFEL
Keywords: X-ray Science
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Rune Berg
Associate professor, Department of Neuroscience
Keywords: neuroscience
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Simon Erlendsson
Assistant professor, Center for Protein Research
Structural Neurobiology
Keywords: Neurobiology, Structural biology, In situ Structural biology, Protein Chemistry, CryoEM, CryoET
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Sine Larsen
Professor, Department Of Chemistry
Structure and function of enzymes, and proteins involved in malaria.
Keywords: carbohydrate active enzymes; enzymes involved in nucleotide metabolism
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Stephan Alexander Pless
Associate professor, Drug Design and Pharmacology Department
Structure-function studies of ion channels (electrophysiology, unnatural amino acids, fluorometry assays)
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Søren Gøgsig Faarup Rasmussen
Associate professor, Department of Neuroscience
Keywords: GPCR, 7TM, G protein coupled receptor activation, signal transduction, monoamine transporters
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Thomas Miller
Associate professor, Department of Cellular and Molecular Medicine
Molecular mechanisms of eukaryotic DNA replication and replication-coupled DNA repair studied with biochemical, biophysical and structural approaches, including cryo-EM.
Keywords: DNA replication, cryo-EM
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Thomas Hamelryck
Associate professor, Bioinformatics Centre, Department of Biology and Image Group, Department of Computer Science
Understanding protein structure and protein structure evolution using probabilistic models and machine learning.
Keywords: Bayesian statistics, probabilistic programming, machine learning, directional statistics
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Thomas Michael Frimurer
Associate professor, Center for Basic Metabolic Research
Chemical and Molecular Receptology
Keywords: Structural biology, Molecular modeling of alternative functional states , Design of pharmacological tool compounds, Structure based drug discovery and optimization, Structural chemical genomics, 7TM, G-Protein Coupled Receptors
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Thue W. Schwartz
Professor, Center for Basic Metabolic Research
Physiological function and pharmacological or therapeutic potential of G protein-coupled receptors
Keywords: 7TM receptors, GPCR, obesity, diabetes, enteroendocrinology
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Ulrik Gether
Professor, Center for Neuroscience
The overall purpose of our research is to achieve insight into molecular, cellular and genetic processes responsible for synaptic signal transmission and how these processes can be modulated by drugs. We have a specific focus on neurotransmitter receptors and transporters with interest in their structure, mechanism and cellular regulation.
Keywords: neurotransmitter receptors, neurotransmitter transporters, structure, cell biology, single molecule microscopy, molecular neuropharmacology
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Vito Foderà
Associate professor, Department of Pharmacy
Molecular mechanisms leading to protein self-assembly and characterization of the physico-chemical properties of protein aggregates.
Keywords: Protein Aggregation, Amyloid-like Superstructures, Protein-Membrane Interactions, Polymers, Theoretical Models for Self-Assembly, Protein-based Biomaterials
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Weria Pezeshkian
Assistant professor, Niels Bohr International Academy, Niels Bohr Institute
Computational microscopy of biological systems, from atomistic to mesoscopic
Keywords: Computational Microscopy
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Wouter Boomsma
Assistant professor, Department of Computer Science
Improving the methodology for molecular simulation, and using Machine Learning to provide more accurate models of the structural preferences in proteins.
Keywords: Molecular simulation, Machine Learning