Meet the scientists of ISBUC

Alexander  Schultz

Professor, Department of Plant and Environmental Science, Section for Transport Biology

Structure-function relationship of symplasmic transport in plants using non-invasive Bioimaging to visualise and quantify plant cell communication across plas­mo­des­mata

Keywords: Plasmodesmays communication phloem

Amelie Stein

Assistant professor, Department of Biology

Consequences of protein sequence changes on structure, function and phenotype

Keywords: structural computational biology, variant consequences, MAVE

Anja Tatiana Ramstedt Jensen

Professor, Department of Immunology and Microbiology

Structural and in vitro molecular and immunological characterization of proteins associated with severe malaria in young children.

Keywords: malaria, pathogenesis, immunity, variant surface antigens, ICAM1, adhesion, molecular interactions, immunology and the immune defence, malaria immunology, malaria vaccine

Annette Eva Langkilde

Associate professor, Department of Drug Design and Pharmacology

Structural analysis of proteins in solution. SAXS. Protein protein interactions. Protein fibrillation and formation of amyloids and amyloid-like structures.

Birthe B. Kragelund

Professor, Department of Biology

Dynamic Protein-Protein Interactions - Understanding Functional Interactions from a Structural Dynamics Platform

Keywords: NMR, Intrinsically Disordered Proteins, membrane proteins, protein interactions

Celine Galvagnion-Büll

Associate professor, Department of Drug Design and Pharmacology

Our research aims at providing mechanistic insights into the interplay between disruptions in lipid homeostasis and Parkinson's Disease. We use a multidisciplinary approach at the interface between biology and biophysics including the study of different patients derived samples and the characterisation of protein-membrane interactions and aggregation at the molecular level.

Keywords: Parkinson's disease, Amyloid fibrils, Alpha-synuclein, Lipid, Kinetic analysis, Biophysics, Cellular biology, Molecular biology

Christian Adam Olsen

Professor, Center for Biopharmaceuticals

Synthesis and evaluation of biologically active peptidomimetics and macrocyclic peptides

Keywords: Foldamers, macrocycles, post translational modifications, epigenetics, affinity-based probes

Claus Juul Løland

Professor, Department of Neuroscience

Elucidation of structure-function relationships in secondary active transporters

Keywords: neurotransmitter transporters, fluorescence, x-ray crystallography, functional reconstitution, membrane protein purification, molecular pharmacology, drug discovery,

David Gloriam

Associate professor, Drug Design and Pharmacology Department

Structure-based drug design and GPCR crystallography

Keywords: GPCR, computational drug design, crystallisation construct design, database development

Dimitrios Stamou

Professor, Department of Chemistry

Disruptive technologies to study the biophysical properties of membranes and membrane proteins on the nanoscale using fluorescence microscopy.

Keywords: Nanoscale membrane biophysics, membrane proteins, membrane curvature, single molecules, fluorescence microscopy, Ras, G protein coupled receptors, primary and secondary active transporters.

Eva Kummer

Associate professor, Novo Nordisk Foundation Center for Protein Research

Working Principles of Molecular Machines involved in Mitochondrial Genome Maintenance & Gene Expression

Keywords: mitochondria, protein-DNA interactions, protein-RNA interactions, electron microscopy, biophysics, biochemistry

Flemming Steen Jørgensen

Professor, Department of Drug Design and Pharmacology

Computational chemistry and prediction of drug metabolism

Guillermo Montoya

Professor, Novo Nordisk Foundation Center for Protein Science

Molecular understanding of macromolecules involved in cell cycle and genome instability.

Keywords: protein-DNA interaction, X-ray, Electron Microscopy, Biophysics

Henriette Autzen

Associate professor, Section for Biomolecular Sciences and SBiNLab

Structural and functional xharacterization of mammalian membrane proteins involved in taste-signaling with single-particle cryo-EM and complimentary techniques.

Keywords: cryo-EM, membrane proteins, pharmacology, biochemistry

Jacob Kirkensgaard

Associate professor, Food

Soft matter self-assembly, structural food science - primarily using small-angle scattering but also light scattering, rheology, imaging and coarse grained simulations

Keywords: self-assembly structural food science soft matter

Jan Jensen

Professor, Department Of Chemistry

Protein structure prediction and validation using NMR. Computational enzyme catalysis and design.

Keywords: Computational Chemistry

Jette Sandholm Kastrup

Professor, Department of Drug Design and Pharmacology

The goal is to obtain detailed understanding of ligand-gated ion channel receptor structure and function, which is essential for providing a rational basis for design of therapeutic strategies for treating diseases and disorders within the central nervous system.

Keywords: Structural biology on receptors and soluble domains hereof; protein X-ray and neutron crystallography, protein-ligand and protein-protein interactions, structure-based ligand design; ionotropic glutamate receptors

Joseph Rogers

Associate professor, Department of Drug Design and Pharmacology

Discovery of new drug-like cyclic peptides for disease-relevant proteins, including biophysical and structural characterisation of the discovered molecules.

Keywords: Peptide display, Unnatural amino acids, Cyclic peptides, Protein folding, Intrinsically disordered proteins

Karen L. Martinez

Associate professor, Dpt of Chemistry & Nano Science Center

Bionanoscience for Membrane Proteins group (BioMeP)
- Use of new biochemical and biophysical tools to investigate membrane proteins isolated and in cells
- Use of nanomaterials for novel cell assays.

Keywords: GPCR, membrane proteins, amphipols, nanodiscs, nanomaterials, surface sensitive techniques,fluorescence,

Kasper D. Rand

Associate professor, Department of Pharmacy

Analysis of the primary structure of proteins by liquid chromatography and mass spectrometry (LC-MS). As well as analysis of the higher-order structure and molecular interactions of proteins and protein systems by hydrogen/deuterium exchange mass spectrometry (HDX-MS).

Keywords: Bioanalytical Chemistry, Protein Analytical Chemistry, HDX-MS, Protein Mass Spectrometry

Kell Mortensen

Professor, Niels Bohr Institute

Biophysics and soft matter studies, with main emphasis on self-assembly, biomaterials and synthetic biology

Klaus Qvortrup

Professor, CFIM (Core Facility for Integrated Microscopy), Department of Biomedical Science

Director of CFIM (Core Facility for Integrated Microscopy)

Keywords: Microscopy

Kresten Lindorff-Larsen

Professor, Department of Biology

Molecular dynamics simulations restrained by experimental data and Relationship between protein structure, function and dynamics

Kaare Teilum

Associate professor, Department of Biology

Link between protein dynamics and function using NMR spectroscopy to look at protein misfiling, enzyme catalysis and membrane transport.

Keywords: NMR, Protein dynamics, enzyme stability

Lars Hviid

Professor, Department of Immunology and Microbiology

Molecular-level interaction between Plasmodium falciparum parasite adhesion ligands and human host endothelial receptor proteins to improve understanding of malaria pathogenesis and immunity

Keywords: malaria, adhesion, pathogenesis, immunity

Lars Bo Stegeager Hemmingsen

Associate professor, Department Of Chemistry

Exploring the role of metal ions in biological systems using various spectroscopic techniques. Current interests: Cu(II) and Zn(II) in Alzheimer's disease, metalloregulatory proteins, ultrasensitive radioisotope based NMR.

Keywords: Metal ions, proteins, spectroscopy

Leila Lo Leggio

Associate professor, Department Of Chemistry

Structural biology of carbohydrate-active, other biotechnology relevant enzymes and  transcription factor.

Keywords: Biochemistry, Carbohydrate-active enzymes, transcription factors

Lise Arleth

Professor, Niels Bohr Institute

Structure and Self-assembly of Lipid and Protein based systems Small-Angle X-ray and Neutron Scattering (SAXS/SANS) experiments and analysis

Martin Gustavsson

Assistant professor, Department of Biomedical Sciences

Structure, dynamics and function of 7TM G protein-coupled receptors.

Keywords: Membrane proteins, 7TM receptors, protein-protein and protein-lipid interactions, receptor pharmacology and signaling

Martin Willemoës

Associate professor, Linderstrøm-Lang Centre for Protein Science

Enzyme engineering and design. Development of selection systems for accelerated evolution of enzyme activities.

Keywords: enzymology, protein engineering, bacterial genetics

Mette Marie Rosenkilde

Professor, Department of Neuroscience and Pharmacology

Basic pharmacology within the area of 7TM receptors

Keywords: incretin hormones, 7TM G protein coupled receptors, virus-exploited 7TM receptors

Michael Gajhede

Professor, Drug Design and Pharmocology Department

Michal Tomasz Marzec

Associate professor, Department of Biomedical Sciences

Proinsulin folding- new necessary steps (type 2 diabetes) and their relationship to degradation and antigen presentation (type 1 diabetes).

Keywords: protein folding, endoplasmic reticulum

Morten Bjerrum

Professor, Department of Chemistry

Bioinorganic Chemistry - Metal ions in biological systems: structure, function, binding, shuttling and exchange - Structure and function of redox active metalloenzymes in metabolic and biotechnological processes

Keywords: Bioinorganic Chemistry

Morten Meldal

Professor, Center for Evolutionary Chemical Biology

Artificial small molecule antibodies and enzymes for medicine and diagnostics using state of the art combinatorial technology

Keywords: Molecular recognition and processing, Artificial antibodies and enzymes, Combinatorial technology, Peptide - organic solid phase synthesis, Polymers, Cell signaling, Molecular modelling and NMR spectroscopy.

Nicholas M I Taylor

Associate professor, Novo Nordisk Foundation Centre for Protein Research

Structural Biology of Molecular Machines

Keywords: cryo-electron microscopy (cryo-EM), structural biology, bacteriophages, bacterial secretion systems, contractile injection systems, membrane transport

Nikos Hatzakis

Associate professor, Nano Science Center

Advanced fluorescent microscopy and single molecule techniques for deciphering protein dynamics and their role in regulation of protein activity and plasticity

Keywords: Single molecule, microscopy, biophysics,

Osman  Mirza

Associate professor, Department of Drug Design and Pharmacology

Interplay between (un)natural compounds and secondary transporters involved in health and disease.

Keywords: X-ray crystallography, EM, Transporters, Structure, Function

Per Mårten Hägglund

Associate professor, Department of Biomedical Sciences

Mechanisms of protein oxidation and its influence on protein structure and function

Keywords: Mass spectrometry, protein oxidation, cross-linking, extracellular matrix proteins

Peter Waaben Thulstrup

Associate professor, Department Of Chemistry

Protein and nucleic acid structures and development of their synthetic modification as tools to investigate aspects of biological chemistry

Keywords: Circular dichroism, fluorescence, electronic structure, excited states, pharmaceutical proteins, bioinorganic chemistry, metal ions, nanoclusters, biosensors

Pontus Gourdon

Associate professor, Department of Biomedical Science

The overarching aim is to reveal the molecular principles and determinants of medically relevant transport processes across cellular membranes

Keywords: membrane proteins, structure, function

Poul Martin Bendix

Associate professor, Niels Bohr Institute

Mechanosensing of cell shapes and dynamics of membrane proteins using advanced optical tools.

Keywords: Filopodia dynamics, membrane curvature, membrane tubes, BAR domain proteins, optical manipulation of membranes, Optically controlled fusion of membranes and cells

Robert Feidenhans’l

Professor, European XFEL

Keywords: X-ray Science

Simon  Erlendsson

Assistant professor, Center for Protein Research

Structural Neurobiology

Keywords: Neurobiology, Structural biology, In situ Structural biology, Protein Chemistry, CryoEM, CryoET

Sine Larsen

Professor, Department Of Chemistry

Structure and function of enzymes, and proteins involved in malaria.

Keywords: carbohydrate active enzymes; enzymes involved in nucleotide metabolism

Stephan Alexander Pless

Associate professor, Drug Design and Pharmacology Department

Structure-function studies of ion channels (electrophysiology, unnatural amino acids, fluorometry assays)

Søren Gøgsig Faarup Rasmussen

Associate professor, Department of Neuroscience

Keywords: GPCR, 7TM, G protein coupled receptor activation, signal transduction, monoamine transporters

Thomas Miller

Associate professor, Department of Cellular and Molecular Medicine

Molecular mechanisms of eukaryotic DNA replication and replication-coupled DNA repair studied with biochemical, biophysical and structural approaches, including cryo-EM.

Keywords: DNA replication, cryo-EM

Thomas Hamelryck

Associate professor, Bioinformatics Centre, Department of Biology and Image Group, Department of Computer Science

Understanding protein structure and protein structure evolution using probabilistic models and machine learning.

Keywords: Bayesian statistics, probabilistic programming, machine learning, directional statistics

Thomas Michael Frimurer

Associate professor, Center for Basic Metabolic Research

Chemical and Molecular Receptology

Keywords: Structural biology, Molecular modeling of alternative functional states , Design of pharmacological tool compounds, Structure based drug discovery and optimization, Structural chemical genomics, 7TM, G-Protein Coupled Receptors

Thor Christian Møller

Assistant professor, Department of Drug Design and Pharmacology

Molecular pharmacology of G protein-coupled receptors

Thue W. Schwartz

Professor, Center for Basic Metabolic Research

Physiological function and pharmacological or therapeutic potential of G protein-coupled receptors

Keywords: 7TM receptors, GPCR, obesity, diabetes, enteroendocrinology

Ulrik Gether

Professor, Center for Neuroscience

The overall purpose of our research is to achieve insight into molecular, cellular and genetic processes responsible for synaptic signal transmission and how these processes can be modulated by drugs. We have a specific focus on neurotransmitter receptors and transporters with interest in their structure, mechanism and cellular regulation.

Keywords: neurotransmitter receptors, neurotransmitter transporters, structure, cell biology, single molecule microscopy, molecular neuropharmacology

Vito Foderà

Associate professor, Department of Pharmacy

Molecular mechanisms leading to protein self-assembly and characterization of the physico-chemical properties of protein aggregates.

Keywords: Protein Aggregation, Amyloid-like Superstructures, Protein-Membrane Interactions, Polymers, Theoretical Models for Self-Assembly, Protein-based Biomaterials

Wouter Boomsma

Assistant professor, Department of Computer Science

Improving the methodology for molecular simulation, and using Machine Learning to provide more accurate models of the structural preferences in proteins.

Keywords: Molecular simulation, Machine Learning