Programme – University of Copenhagen

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ISBUC Annual Meeting Programme

Klik on the programme below to open programme in pdf version or read abstracts below the programme.

ISBUC Annual Meeting Programme

The programme for the ISBUC Annual Meeting includes 5 talks by external and internal speakers as well as ample opportunity for networking at all career levels. 

You are encouraged to sign up for flash talks and posters upon registering for the event.

Main speakers:

Cell division: learning from reconstitution

Andrea Mussachio, Max-Planck Institute of Molecular Physiology, Dortmund

Our laboratory is interested in the molecular basis of chromosome segregation and of its feedback control. We approach this complex problem through a combination of in vitro biochemical reconstitution, structural analysis, and cell biological validation methodologies. Chromosome segregation crucially depends on the function of kinetochores, proteinaceous structures that assemble on specialised chromatin domains called centromeres. In our recent work, we have reconstituted a large fraction of the kinetochore, setting the basis for future functional and structural investigations of its main features. We have also reconstituted the workings of a cell cycle checkpoint, the spindle assembly checkpoint, which receives inputs from the kinetochore to regulate cell cycle progression during mitosis. In my presentation, I will report on these recent results and on the practical and conceptual challenges lying ahead of us.

Neutron protein crystallography and life science research opportunities at ESS

Zoe Fisher, ESS, Lund

Neutron scattering methods offer a powerful and complementary approach to other techniques commonly used in structural biology. Neutrons are uniquely sensitive to 1H and 2H atoms and can provide detailed information on biological materials where hydrogen atoms are abundant. There are a number of methods that use neutrons for life science research, including but not limited to: crystallography, reflectometry, small angle scattering, spin echo spectroscopy, and potentially imaging. Neutron protein crystallography exploits the isotope sensitivity and provides atomic resolution information on Hydrogen bonds, protonation state of amino acid residues, water molecule orientation, and  can report on the electrostatics involved in ligand binding. At the ESS there will be a suite of world-leading neutron instruments, covering a broad range of energies and length scales suitable for the study of biological materials. Some examples of these will be shown, with the largest focus on neutron protein crystallography and how it has been used for structural enzymology and drug binding studies.

Transport across membranes: near-atomic resolution insights from cryo-EM

Nicholas Taylor, C-CINA, Biozentrum, University of Basel

Nicholas is an expert in cryo-EM. In his talk, he will present state-of-the-art possibilities witht the new cryo-EM-setup at CPR.

European XFEL – a new opportunity for structural biology

Robert Feidenhansl', European XFEL

Robert is heading the european XFEL in Hamburg that has recently become operational. At the meeting he will present some of the possibilities you will have as a researcher at the new facility.

Membrane interactions of amphiphilic peptides – importance for antimicrobial, anti-inflammatory, and anticancer properties

Martin Malmsteen, University of Copenhagen

Membrane interactions play an important role for a range of therapeutically interesting properties of amphiphilic peptides, including their antimicrobial, anti-inflammaory, and anticancer effects. The present overview exemplifies some of our recent work on how biophysical investigations with model lipid bilayers can be combined with biological experiments to clarify modes-of-action, and allow peptide optimization towards therapeutic development. For antimicrobial and anticancer effects, the importance of membrane lipid composition is addressed in some detail, whereas peptide interactions with non-lipid membrane components play a key role for peptide anti-inflammatory properties. In exemplifying these effects, emphasis is placed on biologically relevant models for probing peptide interactions with membranes and membrane components, and the combination such systems with investigations in complex biological situations, both in vitro and in vivo. In addition, beneficial effects of delivery systems for such peptide therapeutics are outlined and exemplified.